Diabetes insipidus (DI) , Dr Rajesh Gubba - Internal medicine HD

Diabetes insipidus (DI) is a disorder in which polyuria due to decreased collecting tubule water reabsorption is induced by either decreased secretion of antidiuretic hormone (ADH) (central DI) or resistance to its renal effects (nephrogenic DI). In most patients, the degree of polyuria is primarily determined by the degree of ADH deficiency or resistance . Thus, the urine output may range from 2 L/day with mild partial DI to over 10 to 15 L/day in patients with severe disease.