Sodium reabsorption in distal tubule and collecting duct HD

Sodium is reabsorbed across ENaC channels in principal cells of the late distal tubule and collecting duct, driven by a gradient created by Na/K ATPase. Sodium reabsorption in early distal tubule is via sodium chloride cotransporter The transporters can be blocked by thiazide diuretics and potassium sparring diuretics